Unscrambling an egg: protein disaggregation by AAA+ proteins

  title={Unscrambling an egg: protein disaggregation by AAA+ proteins},
  author={Jimena Weibezahn and Bernd Bukau and Axel Mogk},
  journal={Microbial Cell Factories},
  pages={1 - 1}
Aprotein quality control system, consisting of molecular chaperones and proteases, controls the folding status of proteins and prevents the aggregation of misfolded proteins by either refolding or degrading aggregation-prone species. During severe stress conditions this protection system can be overwhelmed by high substrate load, resulting in the formation of protein aggregates. In such emergency situations, Hsp104/ClpB becomes a key player for cell survival, as it has the extraordinary… CONTINUE READING