Unscheduled apoptosis during acute inflammatory lung injury

  title={Unscheduled apoptosis during acute inflammatory lung injury},
  author={Lin L. Mantell and Jeffrey A. Kazzaz and Jing Xu and Thomas A Palaia and Bruno Piedboeuf and Stephen W. Hall and Gregory C Rhodes and Gang Niu and Alan F Fein and Stuart Horowitz},
  journal={Cell Death and Differentiation},
Apoptosis is a mode of cell death currently thought to occur in the absence of inflammation. In contrast, inflammation follows unscheduled events such as acute tissue injury which results in necrosis, not apoptosis. We examined the relevance of this paradigm in three distinct models of acute lung injury; hyperoxia, oleic acid, and bacterial pneumonia. In every case, it was found that apoptosis is actually a prominent component of the acute and inflammatory phase of injury. Moreover, using… CONTINUE READING


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