Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells.

@article{Ku2011UnsaturatedFA,
  title={Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells.},
  author={Chai Siah Ku and Heather E. Rasmussen and Youngki Park and Elliot Jesch and Jiyoung Lee},
  journal={Nutrition research},
  year={2011},
  volume={31 4},
  pages={278-85}
}
Adenosine triphosphate-binding cassette transporter A1 (ABCA1) plays a critical role in the formation and metabolism of high-density lipoproteins (HDLs). Adenosine triphosphate-binding cassette transporter A1 in the liver and small intestine, in particular, accounts for approximately 90% of plasma HDL cholesterol. Therefore, any alterations in the hepatic and intestinal expression of ABCA1 could have a large impact on HDL biogenesis. We tested the hypothesis that ABCA1 expression is regulated… CONTINUE READING