Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.

@article{Ou2001UnsaturatedFA,
  title={Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.},
  author={Joyce J Ou and Hong Hai Tu and Bei Shan and Arnold Luk and Russell A. DeBose-Boyd and Yuriy K Bashmakov and Joseph L Goldstein and Michael Scott Brown},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 11},
  pages={6027-32}
}
Sterol regulatory element-binding protein-1c (SREBP-1c) enhances transcription of genes encoding enzymes of unsaturated fatty acid biosynthesis in liver. SREBP-1c mRNA is known to increase when cells are treated with agonists of liver X receptor (LXR), a nuclear hormone receptor, and to decrease when cells are treated with unsaturated fatty acids, the end products of SREBP-1c action. Here we show that unsaturated fatty acids lower SREBP-1c mRNA levels in part by antagonizing the actions of LXR… CONTINUE READING
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