Unruptured intracranial aneurysms: their illusive natural history and why subgroup statistics cannot provide normative criteria for clinical decisions or selection criteria for a randomized trial.

@article{Raymond2008UnrupturedIA,
  title={Unruptured intracranial aneurysms: their illusive natural history and why subgroup statistics cannot provide normative criteria for clinical decisions or selection criteria for a randomized trial.},
  author={Jean Raymond and Daniel Roy and Alain Weill and F Guilbert and tristan. nguyen and Andrew J. Molyneux and Allan J. Fox and S C Johnston and C Cognard and L Pierot and J-F Meder and Isabelle Rouleau},
  journal={Journal of neuroradiology. Journal de neuroradiologie},
  year={2008},
  volume={35 4},
  pages={210-6}
}
There is currently no evidence that treatment of unruptured aneurysms is beneficial. Confronted with the uncertainty, many clinicians are attracted by an individual calculus of risks using numbers extracted from subgroup statistics of observational studies or natural history data. The so-called natural history of unruptured aneurysms refers to a purely man… CONTINUE READING