Unrip is a component of SMN complexes active in snRNP assembly.

  title={Unrip is a component of SMN complexes active in snRNP assembly.},
  author={Claudia Carissimi and Jennifer Baccon and Marco Straccia and Pieranna Chiarella and Alessio Maiolica and Alan M. Sawyer and Juri Rappsilber and Livio Pellizzoni},
  journal={FEBS letters},
  volume={579 11},
A macromolecular complex containing survival of motor neurons (SMN), the spinal muscular atrophy protein, and Gemin2-7 interacts with Sm proteins and snRNAs to carry out the assembly of these components into spliceosomal small nuclear ribonucleoproteins (snRNPs). Here we report the characterization of unr-interacting protein (unrip), a GH-WD protein of unknown function, as a component of the SMN complex that interacts directly with Gemin6 and Gemin7. Unrip also binds a subset of Sm proteins… CONTINUE READING


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