Unresponsiveness of insulinoma cells to secretin: significance of the secretin test in patients with insulinoma.


It is well known that B cells in the pancreas release insulin when stimulated by secretin, but there have been few reports on the response of insulinoma cells to secretin. In five patients with insulinoma, changes in serum immunoreactive insulin (IRI) concentration were measured after the intravenous injection of secretin into the peripheral vein before and… (More)


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