Unresponsiveness of hepatic nitrogen metabolism to glucagon infusion in patients with cirrhosis: dependence on liver cell failure.

@article{Fabbri1993UnresponsivenessOH,
  title={Unresponsiveness of hepatic nitrogen metabolism to glucagon infusion in patients with cirrhosis: dependence on liver cell failure.},
  author={Angela Fabbri and Giulio Marchesini and Giulia Bianchi and Ellisabetta Bugianesi and Lucia Bortoluzzi and Marco Zoli and Emilio Pisi},
  journal={Hepatology},
  year={1993},
  volume={18 1},
  pages={28-35}
}
Glucagon exerts an up-regulatory effect on hepatic nitrogen metabolism in healthy subjects, but its potential role in the presence of liver failure is uncertain. The effects of glucagon on urea synthesis and hepatic nitrogen clearance during alanine infusion were studied in five control subjects and six cirrhotic patients in paired experiments at spontaneous glucagon concentrations and at high physiological glucagon levels (approximately 300 to 500 pmol.L-1) induced by a 7.5-hr continuous… CONTINUE READING

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