Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells.

@article{Ingram2005UnresolvedQC,
  title={Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells.},
  author={D. Ingram and N. Caplice and M. Yoder},
  journal={Blood},
  year={2005},
  volume={106 5},
  pages={
          1525-31
        }
}
The field of vascular biology has been stimulated by the concept that circulating endothelial progenitor cells (EPCs) may play a role in neoangiogenesis (postnatal vasculogenesis). One problem for the field has been the difficulty in accurately defining an EPC. Likewise, circulating endothelial cells (CECs) are not well defined. The lack of a detailed understanding of the proliferative potential of EPCs and CECs has contributed to the controversy in identifying these cells and understanding… Expand
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This review provides an overview of cellular‐based therapeutic concepts and the therapeutic potential of ex vivo generated endothelial progenitor cells (EPC) and their role in vasculogenesis and tumor targeting. Expand
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TLDR
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