Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice.

@article{Chen2008UnregulatedCD,
  title={Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice.},
  author={Linan Chen and Yunmin Ding and Barbara Cagniard and Amber Van Laar and Amanda R. Mortimer and Wanhao Chi and Teresa G Hastings and Un Jung Kang and Xiaoxi Zhuang},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 2},
  pages={
          425-33
        }
}
The role of dopamine as a vulnerability factor and a toxic agent in Parkinson's disease (PD) is still controversial, yet the presumed dopamine toxicity is partly responsible for the "DOPA-sparing" clinical practice that avoids using L-3,4-dihydroxyphenylalanine (L-DOPA), a dopamine precursor, in early PD. There is a lack of studies on animal models that directly isolate dopamine as one determining factor in causing neurodegeneration. To address this, we have generated a novel transgenic mouse… CONTINUE READING

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