Unregulated IL-23/IL-17 immune response in autoimmune diseases.

  title={Unregulated IL-23/IL-17 immune response in autoimmune diseases.},
  author={Vin{\'i}cius Silva Costa and Teresa Cristina Colvara Mattana and Maria Elizabeth Rossi da Silva},
  journal={Diabetes research and clinical practice},
  volume={88 3},
INTRODUCTION Type 1A diabetes (T1D) is an autoimmune disease resulting from the selective destruction of pancreatic beta cells by T cells most likely due to interaction of environmental and genetic factors. The CD4(+) T cells, largely implicated in this disease, comprise different subsets; based on the cytokines they produce. These subsets include Th1, Th2, regulatory T cells and another population of recently described T cells called Th17 cells. Increased expression of interleukin 17 (IL-17… CONTINUE READING


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