Unrecognized preclinical Alzheimer disease confounds rs-fcMRI studies of normal aging.

@article{Brier2014UnrecognizedPA,
  title={Unrecognized preclinical Alzheimer disease confounds rs-fcMRI studies of normal aging.},
  author={Matthew R. Brier and Jewell B. Thomas and Abraham Z. Snyder and Liang Wang and Anne M. Fagan and Tammie L. Benzinger and John C. Morris and Beau M. Ances},
  journal={Neurology},
  year={2014},
  volume={83 18},
  pages={1613-9}
}
OBJECTIVE To determine whether, and to what degree, preclinical Alzheimer disease (AD) confounds studies of healthy aging where "healthy" is based on cognitive normality alone. METHODS We examined the effects of preclinical AD in cognitively normal older individuals using resting-state functional connectivity MRI. We investigated 2 groups of cognitively normal participants: one group with evidence of preclinical AD as assessed by CSF markers of AD and the other group with normal CSF… CONTINUE READING

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