Unravelling the pathogenesis of inflammatory bowel disease

@article{Xavier2007UnravellingTP,
  title={Unravelling the pathogenesis of inflammatory bowel disease},
  author={R. J. Xavier and Daniel k. Podolsky},
  journal={Nature},
  year={2007},
  volume={448},
  pages={427-434}
}
Recently, substantial advances in the understanding of the molecular pathogenesis of inflammatory bowel disease (IBD) have been made owing to three related lines of investigation. First, IBD has been found to be the most tractable of complex disorders for discovering susceptibility genes, and these have shown the importance of epithelial barrier function, and innate and adaptive immunity in disease pathogenesis. Second, efforts directed towards the identification of environmental factors… Expand

Paper Mentions

Observational Clinical Trial
A feasibility study for assessing and recording myoelectric activity in patients for early detection of flare in patients with Crohn's disease and differentiating the myoelectric… Expand
ConditionsCrohn Disease
InterventionDevice
Interventional Clinical Trial
Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD), are chronic relapsing inflammatory conditions of the gastrointestinal tract. IBD is… Expand
ConditionsInflammatory Bowel Diseases, Vitamin D Deficiency
InterventionDietary Supplement
[Immunopathogenesis of inflammatory bowel disease].
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Current etiological hypothesis of IBD is presented which argue that pathogenic intestinal bacteria and/or infectious agents initiate and perpetuate the inflammation of the gut in an individual with genetic vulnerability leading to impaired epithelial barrier function and abnormal mucosal immune responses. Expand
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The aspects of the immunopathogenesis of IBD, with focus on mucosal immunity, are reviewed, and mechanisms of action for current and emerging biological therapies are discussed. Expand
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Some of the major immunological defects documented in IBD are reviewed and why compounds inhibiting soluble cytokines were not beneficial in patients and how to optimize therapeutic strategies with biologics are discussed. Expand
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  • Q. Guan
  • Medicine
  • Journal of immunology research
  • 2019
TLDR
This review systemically reviewed the pathogenesis of IBD and highlighted recent advances in host genetic factors, gut microbiota, and environmental factors and, especially, in abnormal innate and adaptive immune responses and their interactions, which may hold the keys to identify novel predictive or prognostic biomarkers and develop new therapies. Expand
The molecular biology of inflammatory bowel diseases.
TLDR
Animal models of IBD have been developed to gain further knowledge of the disease mechanisms and these topics form an overlapping background to enable an improved understanding of the molecular features of these diseases. Expand
Environmental Triggers for IBD
TLDR
The environmental influences are placed in the context of their potential contribution to the development of the pathophysiology of IBD to achieve a greater understanding of the contribution of these factors to dysbiosis and aspire to restoring a healthy microbiome to treat flares and ideally prevent the development and its complications. Expand
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TLDR
The impact of pathogenic and commensal bacteria on IBD-like pathogenesis in mouse infection models is focused on and important recent developments are summarized. Expand
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TLDR
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TLDR
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