Unravelling the mechanisms of mercury hepatotoxicity in wild fish (Liza aurata) through a triad approach: bioaccumulation, metabolomic profiles and oxidative stress.

@article{Brando2015UnravellingTM,
  title={Unravelling the mechanisms of mercury hepatotoxicity in wild fish (Liza aurata) through a triad approach: bioaccumulation, metabolomic profiles and oxidative stress.},
  author={F{\'a}tima Pinto Brand{\~a}o and Tiziana Cappello and Joana Raimundo and Maria Ana Santos and Maria Maisano and Angela Mauceri and M{\'a}rio Guilherme Garc{\^e}s Pacheco and Patr{\'i}cia Mendes Pereira},
  journal={Metallomics : integrated biometal science},
  year={2015},
  volume={7 9},
  pages={1352-63}
}
Clarification of the mechanisms of mercury (Hg) toxicity in fish remains challenging. An innovative approach to this clarification is the combined assessment of metabolomic shifts, alterations in the antioxidant system and the risk of oxidative damage, and Hg bioaccumulation. This strategy was applied to the livers of golden grey mullet (Liza aurata) inhabiting an Hg-contaminated system in Aveiro Lagoon, Portugal. Marked changes in both the metabolic profile and the response to antioxidants… CONTINUE READING