Unravelling the functional significance of PCSK9.

  title={Unravelling the functional significance of PCSK9.},
  author={Gilles Lambert},
  journal={Current opinion in lipidology},
  volume={18 3},
PURPOSE OF REVIEW Proprotein convertase subtilisin kexin type 9 (PCSK9) has emerged as a potential target for lowering plasma LDL cholesterol levels. This review summarizes recent studies published in print or online before January 2007 which have investigated the functional significance of this intriguing protease. RECENT FINDINGS Increasing interest in PCSK9 has given rise to landmark epidemiological studies, the generation of animal models, the discovery of new human mutations, as well as… CONTINUE READING

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