Unravelling the effects of the environment and host genotype on the gut microbiome

  title={Unravelling the effects of the environment and host genotype on the gut microbiome},
  author={Aym{\'e} Spor and Omry Koren and Ruth E. Ley},
  journal={Nature Reviews Microbiology},
To what extent do host genetics control the composition of the gut microbiome? Studies comparing the gut microbiota in human twins and across inbred mouse lines have yielded inconsistent answers to this question. However, candidate gene approaches, in which one gene is deleted or added to a model host organism, show that a single host gene can have a tremendous effect on the diversity and population structure of the gut microbiota. Now, quantitative genetics is emerging as a highly promising… CONTINUE READING
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