Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models

@article{Gerondakis2006UnravellingTC,
  title={Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models},
  author={Steve Gerondakis and Raelene J. Grumont and Raffi Gugasyan and Limsoon Wong and Iwao Isomura and Wai-chi Ho and Ashish Banerjee},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={6781-6799}
}
The nuclear factor-κB (NF-κB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we outline studies using mouse models in which the core components of the NF-κB pathway, namely the IκB kinase subunits (IKKα, IKKβ and NEMO), the IκB proteins (IκBα, IκBβ, IκBɛ and Bcl-3) and the five NF-κB transcription factors (NF-κB1, NF-κB2, c-Rel, RelA and… CONTINUE READING
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