Unravelling mitochondrial pathways to Parkinson's disease

  title={Unravelling mitochondrial pathways to Parkinson's disease},
  author={Ivana Celardo and L Miguel Martins and Sonia Gandhi},
  booktitle={British journal of pharmacology},
Mitochondria are essential for cellular function due to their role in ATP production, calcium homeostasis and apoptotic signalling. Neurons are heavily reliant on mitochondrial integrity for their complex signalling, plasticity and excitability properties, and to ensure cell survival over decades. The maintenance of a pool of healthy mitochondria that can meet the bioenergetic demands of a neuron, is therefore of critical importance; this is achieved by maintaining a careful balance between… CONTINUE READING
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