Unravelling global genome organization by 3C-seq.


Eukaryotic genomes exist in the cell nucleus as an elaborate three-dimensional structure which reflects various nuclear processes such as transcription, DNA replication and repair. Next-generation sequencing (NGS) combined with chromosome conformation capture (3C), referred to as 3C-seq in this article, has recently been applied to the yeast and human genomes, revealing genome-wide views of functional associations among genes and their regulatory elements. Here, we compare the latest genomic approaches such as 3C-seq and ChIA-PET, and provide a condensed overview of how eukaryotic genomes are functionally organized in the nucleus.

DOI: 10.1016/j.semcdb.2011.11.003

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@article{Tanizawa2012UnravellingGG, title={Unravelling global genome organization by 3C-seq.}, author={Hideki Tanizawa and Ken-ichi Noma}, journal={Seminars in cell & developmental biology}, year={2012}, volume={23 2}, pages={213-21} }