Unravelling biological macromolecules with cryo-electron microscopy

  title={Unravelling biological macromolecules with cryo-electron microscopy},
  author={Rafael Fernandez-Leiro and Sjors H. W. Scheres},
Knowledge of the three-dimensional structures of proteins and other biological macromolecules often aids understanding of how they perform complicated tasks in the cell. Because many such tasks involve the cleavage or formation of chemical bonds, structural characterization at the atomic level is most useful. Developments in the electron microscopy of frozen hydrated samples (cryo-electron microscopy) are providing unprecedented opportunities for the structural characterization of biological… CONTINUE READING