Unraveling the therapeutic potential of the Hedgehog pathway in cancer

Abstract

Major progress has been made in recent years in the development of Hedgehog (Hh) pathway inhibitors for the treatment of patients with cancer. Promising clinical trial results have been obtained in cancers that harbor activating mutations of the Hh pathway, such as basal cell carcinoma and medulloblastoma. However, for many cancers, in which Hh ligand… (More)
DOI: 10.1038/nm.3389

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