Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.

@article{Verjee2013UnravelingTS,
  title={Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.},
  author={Liaquat Suleman Verjee and Jennifer S N Verhoekx and James Kwok-Kwan Chan and Thomas Krausgruber and Vicky Nicolaidou and David Izadi and Dominique Davidson and Marc Feldmann and Kim S. Midwood and Jagdeep Nanchahal},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 10},
  pages={E928-37}
}
Dupuytren's disease is a very common progressive fibrosis of the palm leading to flexion deformities of the digits that impair hand function. The cell responsible for development of the disease is the myofibroblast. There is currently no treatment for early disease or for preventing recurrence following surgical excision of affected tissue in advanced disease. Therefore, we sought to unravel the signaling pathways leading to the development of myofibroblasts in Dupuytren's disease. We… CONTINUE READING
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Dutch Dupuytren Study Group; German Dupuytren Study Group; LifeLines Cohort Study; BSSH-GODD Consortium (2011) Wnt signaling and Dupuytren’s disease

  • GH Dolmans
  • N Engl J Med
  • 2011
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