Unraveling the physiological complexities of antibiotic lethality.

  title={Unraveling the physiological complexities of antibiotic lethality.},
  author={Daniel J. Dwyer and James J. Collins and Graham C. Walker},
  journal={Annual review of pharmacology and toxicology},
We face an impending crisis in our ability to treat infectious disease brought about by the emergence of antibiotic-resistant pathogens and a decline in the development of new antibiotics. Urgent action is needed. This review focuses on a less well-understood aspect of antibiotic action: the complex metabolic events that occur subsequent to the interaction of antibiotics with their molecular targets and play roles in antibiotic lethality. Independent lines of evidence from studies of the action… 

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