Unraveling the metabolic transformation of tetrazepam to diazepam with mass spectrometric methods

  title={Unraveling the metabolic transformation of tetrazepam to diazepam with mass spectrometric methods},
  author={Birthe Schubert and M. Pavlic and K. Libiseller and H. Oberacher},
  journal={Analytical and Bioanalytical Chemistry},
  • Birthe Schubert, M. Pavlic, +1 author H. Oberacher
  • Published 2008
  • Chemistry, Medicine
  • Analytical and Bioanalytical Chemistry
  • AbstractThe metabolic transformation pathways of the 1,4-benzodiazepine tetrazepam (C16H17ClN2O, average mass: 288.772) were studied with capillary LC-QqTOF-MS and -MS/MS by analyzing human plasma and urine samples collected from healthy volunteers. Each volunteer took 50 mg of tetrazepam, given in the form of one tablet of Myolastan (Sanofi-Synthelabo, Vienna, Austria). Accurate molecular mass measurements in full-scan mode (scan range: 50–700) were used to survey the collected samples for… CONTINUE READING
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