Unraveling the metabolic transformation of tetrazepam to diazepam with mass spectrometric methods

@article{Schubert2008UnravelingTM,
  title={Unraveling the metabolic transformation of tetrazepam to diazepam with mass spectrometric methods},
  author={Birthe Schubert and M. Pavlic and K. Libiseller and H. Oberacher},
  journal={Analytical and Bioanalytical Chemistry},
  year={2008},
  volume={392},
  pages={1299-1308}
}
AbstractThe metabolic transformation pathways of the 1,4-benzodiazepine tetrazepam (C16H17ClN2O, average mass: 288.772) were studied with capillary LC-QqTOF-MS and -MS/MS by analyzing human plasma and urine samples collected from healthy volunteers. Each volunteer took 50 mg of tetrazepam, given in the form of one tablet of Myolastan (Sanofi-Synthelabo, Vienna, Austria). Accurate molecular mass measurements in full-scan mode (scan range: 50–700) were used to survey the collected samples for… Expand
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References

SHOWING 1-10 OF 15 REFERENCES
Biotransformation and pharmacokinetics of tetrazepam in man.
  • 9
Analytical strategies for identifying drug metabolites.
  • 237
Medicolegal aspects of tetrazepam metabolism
  • 11
Application of mass spectrometry for metabolite identification.
  • 118
Gas-phase fragmentation of protonated benzodiazepines.
  • 17
  • PDF
...
1
2
...