• DOI:10.1007/s00216-008-2447-4
Corpus ID: 10967477

Unraveling the metabolic transformation of tetrazepam to diazepam with mass spectrometric methods

@article{Schubert2008UnravelingTM,
  title={Unraveling the metabolic transformation of tetrazepam to diazepam with mass spectrometric methods},
  author={Birthe Schubert and M. Pavlic and K. Libiseller and H. Oberacher},
  journal={Analytical and Bioanalytical Chemistry},
  year={2008},
  volume={392},
  pages={1299-1308}
}

• Birthe Schubert, M. Pavlic, +1 author H. Oberacher
• Published 2008
• Chemistry, Medicine
• Analytical and Bioanalytical Chemistry

AbstractThe metabolic transformation pathways of the 1,4-benzodiazepine tetrazepam (C16H17ClN2O, average mass: 288.772) were studied with capillary LC-QqTOF-MS and -MS/MS by analyzing human plasma and urine samples collected from healthy volunteers. Each volunteer took 50 mg of tetrazepam, given in the form of one tablet of Myolastan (Sanofi-Synthelabo, Vienna, Austria). Accurate molecular mass measurements in full-scan mode (scan range: 50–700) were used to survey the collected samples for… Expand

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