Unraveling the mechanism of radiosensitization by gemcitabine: the role of TP53.

@article{Pauwels2005UnravelingTM,
  title={Unraveling the mechanism of radiosensitization by gemcitabine: the role of TP53.},
  author={Bea Pauwels and Annelies E. C. Korst and Veronique Andriessen and Marc F. D. Baay and Greet G. O. Pattyn and Hilde A. J. Lambrechts and Christel M. J. de Pooter and Filip Lardon and Jan Baptist Vermorken},
  journal={Radiation research},
  year={2005},
  volume={164 5},
  pages={642-50}
}
Gemcitabine has excellent radiosensitizing properties, as shown in both preclinical and clinical studies. Radiosensitization correlated with the early S-phase block of gemcitabine. In the present study, we investigated the role of TP53 in the radiosensitizing effect of gemcitabine. Isogenic A549 cells differing in TP53 status were treated with gemcitabine during the 24 h prior to irradiation. Cell survival was determined 7 days after irradiation by the sulforhodamine B test. In addition, cell… CONTINUE READING