Unraveling the intrafamilial correlations and heritability of tumor types in MEN1: a Groupe d'étude des Tumeurs Endocrines study.

  title={Unraveling the intrafamilial correlations and heritability of tumor types in MEN1: a Groupe d'{\'e}tude des Tumeurs Endocrines study.},
  author={Julien Thevenon and Abderrahmane Bourredjem and Laurence Faivre and Catherine M Cardot-Bauters and Alain Calender and Morgane Le Bras and Sophie Giraud and Patricia Niccoli and Marie Françoise Odou and Françoise Borson-Chazot and Anne Barlier and C Lombard-bohas and Eric Clauser and Antoine Tabarin and Eric Pasmant and Olivier Chabre and Emilie Castermans and Ph Ruszniewski and J{\'e}r{\^o}me Bertherat and Brigitte Delemer and Sophie Christin-Ma{\^i}tre and Alb Beckers and Isabelle Guilhem and Vincent Rohmer and Bernard Goichot and Philippe Caron and Eric Baudin and Philippe Chanson and Lionel Groussin and H{\'e}l{\`e}ne Du Boullay and Georges Weryha and Pierre Lecomte and Frank Schillo and H{\'e}l{\`e}ne Bihan and Françoise Archambeaud and V{\'e}ronique Kerlan and Nathalie Bourcigaux and Jean Marc Kuhn and Bruno Verg{\`e}s and Michel Rodier and M G C Catherine Renard and Jean Louis Sadoul and Christine Binquet and Pierre Goudet},
  journal={European journal of endocrinology},
  volume={173 6},
BACKGROUND MEN1, which is secondary to the mutation of the MEN1 gene, is a rare autosomal-dominant disease that predisposes mutation carriers to endocrine tumors. Most studies demonstrated the absence of direct genotype-phenotype correlations. The existence of a higher risk of death in the Groupe d'étude des Tumeurs Endocrines-cohort associated with a… CONTINUE READING