Unraveling the complex genetic underpinnings of asthma and allergic disorders.

  title={Unraveling the complex genetic underpinnings of asthma and allergic disorders.},
  author={Daniel T Swarr and Hakon Hakonarson},
  journal={Current opinion in allergy and clinical immunology},
  volume={10 5},
PURPOSE OF REVIEW Asthma and other allergic diseases are complex genetic disorders that result from interactions between multiple genes and environmental factors. In this review, we summarize findings from candidate gene analyses, discuss the recent success of genome-wide association (GWA) studies, and outline challenges facing the field. RECENT FINDINGS In the past year, five GWA studies have been reported for asthma, one for atopic dermatitis, and four for intermediate phenotypes using… CONTINUE READING


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