Unraveling the central nervous system pathways underlying responses to leptin

@article{Elmquist1998UnravelingTC,
  title={Unraveling the central nervous system pathways underlying responses to leptin},
  author={Joel K Elmquist and Eleftheria Maratos-Flier and Clifford B. Saper and Jeffrey S. Flier},
  journal={Nature Neuroscience},
  year={1998},
  volume={1},
  pages={445-450}
}
Here we summarize recent progress in the biology of leptin, concentrating on its central nervous system (CNS) actions. The product of the ob gene, leptin is a circulating hormone produced by white adipose tissue that has potent effects on feeding behavior, thermogenesis and neuroendocrine responses. Leptin regulates energy homeostasis, as its absence in rodents and humans causes severe obesity. We consider the physiological mechanisms underlying leptin action, along with several novel… 
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  • Biology, Medicine
    International Journal of Obesity
  • 2001
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Food intake is regulated via neural circuits located in the hypothalamus. During the past decade our knowledge on the specific mediators and neuronal networks that regulate food intake and body
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Activation of sympathetic outflow to a number of tissues that store fat might be an important mechanism through which these peripheral metabolic effects of leptin contribute to the satiating properties of leptin.
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TLDR
The mechanisms by which leptin activates intracellular signaling and the roles of two specific leptin-activated signals [phosphatidylinositol 3-kinase and signal transducer and activator of transcription-3 (STAT3)] in the regulation of body weight and neuroendocrine function are reviewed.
Leptin and insulin action in the central nervous system.
TLDR
Old and recent data implicating insulin and leptin as key circulating signals to the central nervous system, particularly the ventral hypothalamus, in communicating the size and the distribution of body fat stores are summarized.
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