Unraveling the Plasmodium vivax sporozoite transcriptional journey from mosquito vector to human host

@inproceedings{Roth2018UnravelingTP,
  title={Unraveling the Plasmodium vivax sporozoite transcriptional journey from mosquito vector to human host},
  author={Alison Roth and Swamy Rakesh Adapa and Min Zhang and Xiangyun Liao and Vishal Saxena and Raaven Goffe and Suzanne Li and Ratawan Ubalee and Gagandeep Singh Saggu and Zarna Rajeshkumar Pala and Shilpi Garg and Silas A. Davidson and Rays H. Y. Jiang and John H Adams},
  booktitle={Scientific Reports},
  year={2018}
}
Malaria parasites transmitted by mosquito bite are remarkably efficient in establishing human infections. The infection process requires roughly 30 minutes and is highly complex as quiescent sporozoites injected with mosquito saliva must be rapidly activated in the skin, migrate through the body, and infect the liver. This process is poorly understood for Plasmodium vivax due to low infectivity in the in vitro models. To study this skin-to-liver-stage of malaria, we used quantitative bioassays… CONTINUE READING
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