Unraveling the Global microRNAome Responses to Ionizing Radiation in Human Embryonic Stem Cells

@inproceedings{Sokolov2012UnravelingTG,
  title={Unraveling the Global microRNAome Responses to Ionizing Radiation in Human Embryonic Stem Cells},
  author={Mykyta V. Sokolov and Irina V. Panyutin and Ronald D. Neumann},
  booktitle={PloS one},
  year={2012}
}
MicroRNAs (miRNA) comprise a group of short ribonucleic acid molecules implicated in regulation of key biological processes and functions at the post-transcriptional level. Ionizing radiation (IR) causes DNA damage and generally triggers cellular stress response. However, the role of miRNAs in IR-induced response in human embryonic stem cells (hESC) has not been defined yet. Here, by using system biology approaches, we show for the first time, that miRNAome undergoes global alterations in hESC… CONTINUE READING
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