Unraveling the Genetics of Autoimmunity

@article{Zenewicz2010UnravelingTG,
  title={Unraveling the Genetics of Autoimmunity},
  author={Lauren A Zenewicz and Clara Abraham and Richard A Flavell and Judy H Cho},
  journal={Cell},
  year={2010},
  volume={140},
  pages={791-797}
}
The chronic autoimmune diseases include multiple complex genetic disorders. Recently, genome-wide association studies (GWAS) have identified a large number of major loci, with many associations shared between various autoimmune diseases. These associations highlight key roles for lymphocyte activation and prioritize specific cytokine pathways and mechanisms of host-microbe recognition. Despite success in identifying loci, comprehensive models of disease pathogenesis are currently lacking… CONTINUE READING
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