Unraveling the Differences of the Hydrolytic Activity of Trypanosoma cruzitrans-Sialidase and Trypanosoma rangeli Sialidase: A Quantum Mechanics–Molecular Mechanics Modeling Study

@article{BuerenCalabuig2014UnravelingTD,
  title={Unraveling the Differences of the Hydrolytic Activity of Trypanosoma cruzitrans-Sialidase and Trypanosoma rangeli Sialidase: A Quantum Mechanics–Molecular Mechanics Modeling Study},
  author={J. Bueren-Calabuig and Gustavo Pierdominici-Sottile and A. Roitberg},
  journal={The Journal of Physical Chemistry. B},
  year={2014},
  volume={118},
  pages={5807 - 5816}
}
  • J. Bueren-Calabuig, Gustavo Pierdominici-Sottile, A. Roitberg
  • Published 2014
  • Chemistry, Medicine
  • The Journal of Physical Chemistry. B
  • Chagas’ disease, also known as American trypanosomiasis, is a lethal, chronic disease that currently affects more than 10 million people in Central and South America. The trans-sialidase from Trypanosoma cruzi (T. cruzi, TcTS) is a crucial enzyme for the survival of this parasite: sialic acids from the host are transferred to the cell surface glycoproteins of the trypanosome, thereby evading the host’s immune system. On the other hand, the sialidase of T. rangeli (TrSA), which shares 70… CONTINUE READING
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