Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+]

@article{Tessier2009UnravelingIS,
  title={Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+]},
  author={Peter M Tessier and Susan Lindquist},
  journal={Nature Structural &Molecular Biology},
  year={2009},
  volume={16},
  pages={598-605}
}
Prions are proteins that can access multiple conformations, at least one of which is β-sheet rich, infectious and self-perpetuating in nature. These infectious proteins show several remarkable biological activities, including the ability to form multiple infectious prion conformations, also known as strains or variants, encoding unique biological phenotypes, and to establish and overcome prion species (transmission) barriers. In this Perspective, we highlight recent studies of the yeast prion… CONTINUE READING