Unraveling V(D)J Recombination Insights into Gene Regulation

  title={Unraveling V(D)J Recombination Insights into Gene Regulation},
  author={D. Jung and F. Alt},
  • D. Jung, F. Alt
  • Published 2004
  • Biology, Medicine
  • Cell
  • V(D)J recombination assembles antigen receptor genes from component gene segments. We review findings that have shaped our current understanding of this remarkable mechanism, with a focus on two major reports--the first detailed comparison of germline and rearranged antigen receptor loci and the discovery of the recombination activating gene-1. 

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