V(D)J Recombination: Orchestrating Diversity Without Damage
- BiologyReference Module in Life Sciences
Epigenetic regulation of antigen receptor gene rearrangement
- BiologyF1000 biology reports
Recent advances regarding the impact of nuclear organisation and epigenetic-based mechanisms on the regulation of V(D)J recombination are summarized.
Molecular genetics at the T-cell receptor beta locus: insights into the regulation of V(D)J recombination.
- BiologyAdvances in experimental medicine and biology
This chapter summarizes the current knowledge and highlights unanswered questions regarding the regulation of V(D)J recombination at the Tcrb locus, placing emphasis on mouse transgenesis and gene-targeting approaches.
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.
- BiologyAnnual review of immunology
Advances that have been made in understanding how V(D)J recombination at the IgH locus is controlled are summarized and important areas for future investigation are discussed.
RAG Chromatin Scanning During V(D)J Recombination and Chromatin Loop Extrusion are Related Processes.
- BiologyAdvances in immunology
Role of non-homologous end joining in V(D)J recombination
- BiologyImmunologic research
The efforts of a number of laboratories are summarized in providing the mechanisms of V(D)J regulation with a focus on the NHEJ pathway, which allows efficient and regulated generation of the antigen receptors.
Turning T‐cell receptor β recombination on and off: more questions than answers
Evaluated current understanding of developmental regulation at the Tcrb locus highlights the many unresolved issues and discusses how recent concepts emerging from studies of other antigen receptor loci may (or may not) help to resolve these issues.
Reassignment of the murine 3′TRDD1 recombination signal sequence
The variability introduced in signal joints generated after rearrangement of the TR DD1 and TRDD2 genes in murine thymocytes is analyzed and it is shown that the functional TRDD1 recombination signal is shifted inside the putative coding sequence of theTRDD1 gene and, consequently, that this gene is shorter than indicated in the databases.
Gene-specific signal joint modifications during V(D)J recombination of TCRAD locus genes in murine and human thymocytes.
Antigen receptor genes and the evolution of a recombinase.
- BiologySeminars in immunology
SHOWING 1-10 OF 244 REFERENCES
The Mechanism and Regulation of Chromosomal V(D)J Recombination
- Biology, MedicineCell
Gene segment selection in V(D)J recombination: accessibility and beyond
- BiologyNature Immunology
Understanding is increased of how the chromatin barrier to V(D)J recombination is regulated, and how chromatin control and the properties of the underlying recombination signal sequences may cooperate to create diverse, lineage-restricted and allelically excluded repertoires of antigen receptors.
The mechanism of V(D)J recombination: site-specificity, reaction fidelity and immunologic diversity.
- BiologySeminars in immunology
This review focuses on the issues of site-specificity, reaction fidelity and immunologic diversity in the V(D)J recombination reaction.
Cell Type–Specific Chromatin Structure Determines the Targeting of V(D)J Recombinase Activity In Vitro
Impairment of V(D)J recombination in double-strand break repair mutants.
Evidence is provided for two distinct nonlymphoid-specific genes that encode factors involved in both DNA repair and V(D)J recombination in cells deficient in DNA repair.
b of Selective D Gene Utilization in the TCR DNA-Rag Protein Interactions in the Control
It is proposed that selective gene segment usage is controlled at the level of differential assembly and/or stability of synaptic RS complexes, and that evolutionary “deterioration” of the RS motifs may have been important to allow the VDJ recombinase to exert autonomous control over gene segment use during gene rearrangement.
This chapter focuses on V(D)J recombination, but other mechanisms also contribute to antigen receptor diversity, and several new experimental systems should soon lead to a better understanding of locus accessibility, and make experimental modification of rearrangement possible.
Regulation of V(D)J recombination: A dominant role for promoter positioning in gene segment accessibility
- BiologyProceedings of the National Academy of Sciences of the United States of America
Using T cell receptor β substrates that integrate stably into nuclear chromatin, it is shown that promoter location, rather than germ-line transcription or histone acetylation, is a primary determinant of recombination efficiency.
Initiation of V(D)J recombination in vitro obeying the 12/23 rule
It is shown that extracts made from a lymphoid cell line that expresses truncated forms of the Ragl and Rag2 proteins have a signal-cutting activity that obeys the 12/23 rule.