Unraveling V(D)J Recombination Insights into Gene Regulation

  title={Unraveling V(D)J Recombination Insights into Gene Regulation},
  author={David Jung and Frederick W. Alt},

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Advances that have been made in understanding how V(D)J recombination at the IgH locus is controlled are summarized and important areas for future investigation are discussed.

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b of Selective D Gene Utilization in the TCR DNA-Rag Protein Interactions in the Control

It is proposed that selective gene segment usage is controlled at the level of differential assembly and/or stability of synaptic RS complexes, and that evolutionary “deterioration” of the RS motifs may have been important to allow the VDJ recombinase to exert autonomous control over gene segment use during gene rearrangement.

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