Unprotected Amino Acids as Stable Radical Precursors for Heterocycle C-H Functionalization.

An efficient and general method for the C-H alkylation of heteroarenes using unprotected amino acids as stable alkyl radical precursors is reported. This one-pot procedure is performed open to air under aqueous conditions and is effective for several natural and unnatural amino acids. Heterocycles of varying structure are suitably functionalized, and… CONTINUE READING