Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements

@article{Lareau2007UnproductiveSO,
  title={Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements},
  author={Liana F. Lareau and Maki Inada and Richard E. Green and Jordan C. Wengrod and Steven E. Brenner},
  journal={Nature},
  year={2007},
  volume={446},
  pages={926-929}
}
The human and mouse genomes share a number of long, perfectly conserved nucleotide sequences, termed ultraconserved elements. Whereas these regions can act as transcriptional enhancers when upstream of genes, those within genes are less well understood. In particular, the function of ultraconserved elements that overlap alternatively spliced exons of genes… CONTINUE READING

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