Unpredictable saccharin reinforcement enhances locomotor responding to amphetamine.

@article{Singer2012UnpredictableSR,
  title={Unpredictable saccharin reinforcement enhances locomotor responding to amphetamine.},
  author={Bryan F Singer and John Scott-Railton and Paul Vezina},
  journal={Behavioural brain research},
  year={2012},
  volume={226 1},
  pages={340-4}
}
Drug-naïve, non-deprived rats were trained to lever press for saccharin under fixed-ratio (FR) or variable-ratio (VR) schedules of reinforcement. Rats trained on the VR schedule in which saccharin reinforcement was not predicted by a fixed number of lever presses subsequently showed an enhanced locomotor response to a threshold amphetamine challenge injection (0.5mg/kg IP) administered 2 weeks following the last saccharin session. This finding suggests that chronic exposure to gambling-like… CONTINUE READING
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