Unpredictable chronic mild stress not chronic restraint stress induces depressive behaviours in mice.


The chronic stress model was developed on the basis of the stress-diathesis hypothesis of depression. However, these behavioural responses associated with different stress paradigms are quite complex. This study examined the effects of two chronic stress regimens on anxiety-like and depressive behaviours. C57BL/6 mice were subjected to unpredictable chronic mild stress or to chronic restraint stress for 4 weeks. Subsequently, both anxiety-like behaviours (open field, elevated plus maze and novelty suppressed feeding) and depression-like behaviours (tail suspension, forced swim and sucrose preference) were evaluated. Both chronic stress models generated anxiety-like behaviours, whereas only unpredictable chronic mild stress could induce depressive behaviours such as increased immobility and decreased sucrose consumption. These results of the present study provide additional evidence on how chronic stress affects behavioural responses and point to the importance of the validity of animal models of chronic stress in studying depression.

DOI: 10.1097/WNR.0000000000000243
Citations per Year

109 Citations

Semantic Scholar estimates that this publication has 109 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Zhu2014UnpredictableCM, title={Unpredictable chronic mild stress not chronic restraint stress induces depressive behaviours in mice.}, author={Shenghua Zhu and Ruoyang Shi and Junhui Wang and Jun-feng Wang and Xin-Min Li}, journal={Neuroreport}, year={2014}, volume={25 14}, pages={1151-5} }