Unprecedented multiplicity of Ig transmembrane and secretory mRNA forms in the cartilaginous fish.

@article{Rumfelt2004UnprecedentedMO,
  title={Unprecedented multiplicity of Ig transmembrane and secretory mRNA forms in the cartilaginous fish.},
  author={Lynn L. Rumfelt and Marilyn Diaz and Rebecca L. Lohr and Evonne Mochon and Martin F. Flajnik},
  journal={Journal of immunology},
  year={2004},
  volume={173 2},
  pages={1129-39}
}
In most jawed vertebrates including cartilaginous fish, membrane-bound IgM is expressed as a five Ig superfamily (Igsf)-domain H chain attached to a transmembrane (Tm) region. Heretofore, bony fish IgM was the one exception with IgM mRNA spliced to produce a four-domain Tm H chain. We now demonstrate that the Tm and secretory (Sec) mRNAs of the novel cartilaginous fish Ig isotypes, IgW and IgNAR, are present in multiple forms, most likely generated by alternative splicing. In the nurse shark… CONTINUE READING

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