Unprecedented 8,9'-neolignans: enantioselective synthesis of possible stereoisomers for structural determination.

@article{Takahashi2014Unprecedented8E,
  title={Unprecedented 8,9'-neolignans: enantioselective synthesis of possible stereoisomers for structural determination.},
  author={M. Takahashi and Noriyuki Suzuki and T. Ishikawa and H. Huang and Hsun-Shuo Chang and I. Chen},
  journal={Journal of natural products},
  year={2014},
  volume={77 12},
  pages={
          2585-9
        }
}
  • M. Takahashi, Noriyuki Suzuki, +3 authors I. Chen
  • Published 2014
  • Chemistry, Medicine
  • Journal of natural products
  • (+)-Wutaienin (3) and its C-7 methyl ether (4), isolated from Zanthoxylum wutaiense, were found to be unprecedented 8,9'-neolignans containing an (S)-2-(1,1-dimethyl-1-hydroxymethyl)-7-methoxydihydrobenzofuran skeleton. Wutaienin (3) was present in the plant as an inseparable 1:1 mixture of the (7,8)-syn-diastereoisomers. The diastereoisomeric mixture was characterized by comparison with four possible diastereoisomers, which were enantioselectively synthesized from (S)-5-bromo-(1,1-dimethyl-1… CONTINUE READING
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