Corpus ID: 23417802

Unmasking of the inhibitory action of glucose on insulin release after alpha 2-adrenergic activation.

@article{Bergsten1986UnmaskingOT,
  title={Unmasking of the inhibitory action of glucose on insulin release after alpha 2-adrenergic activation.},
  author={P. Bergsten and B. Hellman},
  journal={Biochemical and biophysical research communications},
  year={1986},
  volume={139 2},
  pages={
          557-63
        }
}
Insulin release in response to glucose was measured after culture of islets from ob/ob-mice in a Ca2+-deficient medium. The stimulatory effect of 20 mM glucose disappeared after addition of 1 microM L-epinephrine, and it was reversed into inhibition when the medium contained 0.1 to 10 microM clonidine. Glucose inhibited insulin release also after activation of the alpha 2-adrenoceptors with B-HT 933, whereas blocking of these receptors with idazoxan removed glucose inhibition in the presence of… Expand
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Glucose‐induced inhibition of insulin secretion
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