Unmasking of a novel potassium current in Drosophila by a mutation and drugs.

@article{Singh1999UnmaskingOA,
  title={Unmasking of a novel potassium current in Drosophila by a mutation and drugs.},
  author={Amar Paul Singh and Sanjay Kumar Singh},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 16},
  pages={6838-43}
}
The delayed rectifier potassium current plays a critical role in cellular physiology. This current (I(K)) in Drosophila larvae is believed to be a single current. However, a likely null mutation in the Shab K(+) channel gene (Shab(3)) reduces I(K) but does not eliminate it. This raises a question as to whether or not the entire I(K) passes through channels encoded by one gene. Similarly, an incomplete blockade of I(K) by high concentrations of quinidine, a selective I(K) blocker, raises a… CONTINUE READING

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