Unmasking moles

@article{Bagshawe1982UnmaskingM,
  title={Unmasking moles},
  author={K. D. Bagshawe and Sylvia D. Lawler},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
  year={1982},
  volume={89}
}
  • K. Bagshawe, S. Lawler
  • Published 1 April 1982
  • Biology
  • BJOG: An International Journal of Obstetrics & Gynaecology
Until recently the diagnosis of hydatidiform mole was based on macroscopic appearances and histopathology. It was recognized that it was not a uniform entity and that the histological features varied. Classical or complete mole was defined as a conceptus usually without a fetus in which accumulation of fluid in the mesenchymal core of the villi resulted in visible cysts and was associated with an overgrowth of the trophoblast and an undue tendency to penetrate the uterine wall (Park 1971… 
UK registration scheme for hydatidiform mole 1973–83
  • K. Bagshawe
  • Medicine
    British journal of obstetrics and gynaecology
  • 1986
TLDR
The risk of a pregnancy resulting in hydatidiform mole was lowest between 25 and 29 years when compared with the number of live births in that age group but it increased progressively towards both ends of reproductive life.
Analysis of 309 Cases after Hydatidiform Mole: Different Follow-Up Program According to Biologic Behavior
TLDR
Between 1976 and 1985, at the Obstetrics and Gynecology Department of Milan University, a total of 309 cases of hydatidiform mole, 223 complete moles and 86 partial moles, were monitored with the assay of beta-human chorionic gonadotropin, following a postmolar biochemical surveillance program, confirming the necessity of selection criteria in a diagnosis of GTT.
Molecular genetic studies of complete hydatidiform moles.
TLDR
It is suggested that when using microarray CGH that genotyping using targeted STR analysis should be performed for all POC referrals to aid in the identification of complete hydatidiform moles.
Can histopathologists reliably diagnose molar pregnancy?
TLDR
An atypical growth pattern of trophoblast, rather than the polar accentuation seen in normal first trimester pregnancies, seems to be the important diagnostic histological feature for partial mole.
Parental age and risk of complete and partial hydatidiform mole
TLDR
There were important differences in the epidemiology of complete and partial hydatidiform mole, and older paternal age (>45) was related with the risk of complete mole, but not of partial mole.
Influence of chromosomal determinants on development of androgenetic and parthenogenetic cells.
TLDR
The results suggest that maternal chromosomes in parthenogenetic cells permit their participation in the primitive ectoderm lineage but these cells are presumably eliminated by selective pressure or autonomous cell lethality from the primitive endoderm and trophectoderm lineages.
A Review of the Role of Established Tumour Markers
TLDR
Although their sensitivity for a particular tumour type may be poor, most tumour markers can be used for monitoring the therapy and follow-up of selected marker positive patients and laboratory tumour marker services should be established so that they are appropriate to local oncology specialities.
Paternal responsiblity
TLDR
Soler, N. G. & Hytten, F. E. (1968) The assessment of fetal growth.
Genomic imprinting: a possible mechanism for the parental origin effect in Huntington's chorea.
  • W. Reik
  • Biology
    Journal of medical genetics
  • 1988
TLDR
Experimental evidence suggests genomic imprinting as an alternative mechanism, by which the gene itself becomes modified in a different way depending on whether it is passed through the maternal or the paternal germline, which could result in earlier or higher level expression of the gene when it is transmitted by the father.
Genomic Imprinting: A Specialized Form of GeneRegulation
TLDR
The phenomenon of genomic imprinting, the developmental implications of imprinting and the molecular mechanisms proposed for this process are reviewed.
...
1
2
...

References

SHOWING 1-10 OF 19 REFERENCES
The syndromes of hydatidiform mole. II. Morphologic evolution of the complete and partial mole.
Genetic studies on hydatidiform moles II. The origin of complete moles
TLDR
An investigation of 50 histologically complete hydatidiform moles was by examining the molar tissue after termination of pregnancy, finding that in 27 cases, including the 5 tested who have subsequently required treatment, the mole was homozygous for all genetic markers examined.
Androgenetic origin of hydatidiform mole
TLDR
A cytogenetic study of the origin of hydatidiform mole is made and it is found that it receives only paternal chromosomes and is therefore androgenetic in origin.
Complete (classic) hydatidiform mole with 46,XY karyotype of paternal origin
TLDR
The patient is a 22-year-old Nigerian woman, recently arrived in the USA, who had a classic complete mole removed by suction curettage at 12 weeks' gestation and developed malignant trophoblastic disease, which was successfully treated by chemotherapy, as will be published in detail elsewhere.
Mechanism of origin of complete hydatidiform moles
TLDR
A study of a series of complete moles shows the first alternative to be correct in the majority of cases.
Complete and partial hydatidiform mole in Hawaii: cytogenetics, morphology and epidemiology.
TLDR
The incidence of complete moles was significantly increased in women aged less than 20 years and also in Filipino women, these two effects being independent of one another.
Dispermic origin of XY hydatidiform moles
TLDR
A study of four XY moles is described, and evidence that they result from the fertilization of an empty egg by two haploid spermatozoa is provided.
An analysis of the influences of maternal age, gestational age, contraceptive method, and the mode of primary treatment of patients with hydatidiform moles on the incidence of subsequent chemotherapy.
TLDR
The need for chemotherapy for trophoblastic tumour after evacuation of a hydatidiform mole was found to be two- to three-fold greater in patients who had undergone a medical induction, hysterectomy or hysterotomy compared with those whose hyd atidiform moles had been evacuated by vacuum or surgical curettage, or who had aborted spontaneously.
Reproductive performance of women successfully treated for gestational trophoblastic tumors.
...
1
2
...