Unmasked Brugada pattern by ajmaline challenge in patients with myotonic dystrophy type 1.

Abstract

BACKGROUND Myotonic dystrophy type 1 (DM1) generates missplicing of the SCN5A gene, encoding the cardiac sodium channel (Nav 1.5). Brugada syndrome, which partly results from Nav 1.5 dysfunction and causes increased VF occurrence, can be unmasked by ajmaline. We aimed to investigate the response to ajmaline challenge in DM1 patients and its potential impact… (More)
DOI: 10.1111/anec.12168

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Cite this paper

@article{Pambrun2015UnmaskedBP, title={Unmasked Brugada pattern by ajmaline challenge in patients with myotonic dystrophy type 1.}, author={Thomas Pambrun and Agust{\'i}n Bortone and Patrick Bois and Bruno Degand and Sylvie Patri and Aur{\'e}lie Mercier and Mohamed Chahine and Aurelien Chatelier and Damien Coisne and Alain Amiel}, journal={Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc}, year={2015}, volume={20 1}, pages={28-36} }