Unlocking the mechanisms of HCN channel gating with locked-open and locked-closed channels


457 C o m m e n t a r y Ion channels are highly specialized to respond to a wide range of environmental stimuli, including transmem-brane voltage and chemical ligands (Hille, 2001). The response of channels to external cues causes a change in their ion conduction, which, in turn, modifies the behavior of excitable and nonexcitable cells. The hyper… (More)
DOI: 10.1085/jgp.201210898


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