Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues.

Abstract

Derivatives of the amino acid tryptophan (Trp) serve as precursors for the chemical and biological synthesis of complex molecules with a wide range of biological properties. Trp analogues are also valuable as building blocks for medicinal chemistry and as tools for chemical biology. While the enantioselective synthesis of Trp analogues is often lengthy and… (More)
DOI: 10.1021/jacs.7b05007

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Cite this paper

@article{Romney2017UnlockingRO, title={Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues.}, author={David K Romney and Javier Murciano-Calles and J{\"o}ri E Wehrm{\"u}ller and Frances H. Arnold}, journal={Journal of the American Chemical Society}, year={2017}, volume={139 31}, pages={10769-10776} }