Unlike insulin, amino acids stimulate p70S6K but not GSK-3 or glycogen synthase in human skeletal muscle.

@article{Liu2004UnlikeIA,
  title={Unlike insulin, amino acids stimulate p70S6K but not GSK-3 or glycogen synthase in human skeletal muscle.},
  author={Zhen-qi Liu and Yangsong Wu and Edward W Nicklas and Linda A. Jahn and Wendie J. Price and Eugene J. Barrett},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2004},
  volume={286 4},
  pages={E523-8}
}
Insulin stimulates muscle glucose disposal via both glycolysis and glycogen synthesis. Insulin activates glycogen synthase (GS) in skeletal muscle by phosphorylating PKB (or Akt), which in turn phosphorylates and inactivates glycogen synthase kinase 3 (GSK-3), with subsequent activation of GS. A rapamycin-sensitive pathway, most likely acting via ribosomal 70-kDa protein S6 kinase (p70(S6K)), has also been implicated in the regulation of GSK-3 and GS by insulin. Amino acids potently stimulate… CONTINUE READING
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New insights into the role and mechanism of glycogen synthase activation by insulin

  • Lawrence JC, PJ Roach
  • Diabetes
  • 1997
Highly Influential
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