Unliganded thyroid hormone receptor alpha1 impairs adult hippocampal neurogenesis.

@article{Kapoor2010UnligandedTH,
  title={Unliganded thyroid hormone receptor alpha1 impairs adult hippocampal neurogenesis.},
  author={Richa Kapoor and Max van Hogerlinden and Kristel Wallis and Himanish Ghosh and Kristina Nordstrom and Bjorn Vennstrom and Vidita A. Vaidya},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2010},
  volume={24 12},
  pages={
          4793-805
        }
}
Thyroid hormone regulates adult hippocampal neurogenesis, a process involved in key functions, such as learning, memory, and mood regulation. We addressed the role of thyroid hormone receptor TRα1 in adult hippocampal neurogenesis, using mice harboring a TRα1 null allele (TRα1(-/-)), overexpressing TRα1 6-fold (TRα2(-/-)), and a mutant TRα1 (TRα1(+/m)) with a 10-fold lower affinity to the ligand. While hippocampal progenitor proliferation was unaltered, TRα1(-/-) mice exhibited a significant… CONTINUE READING
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