Unleashing the potential of NOD-and Toll-like agonists as vaccine adjuvants

  title={Unleashing the potential of NOD-and Toll-like agonists as vaccine adjuvants},
  author={Charles Maisonneuvea and Sylvie Bertholetb and Dana J. Philpotta and Ennio De Gregoriob},
  • Charles Maisonneuvea, Sylvie Bertholetb, +1 author Ennio De Gregoriob
  • Published 2014
Innate immunity confers an immediate nonspecific mechanism of microbial recognition through germ line-encoded pattern recognition receptors (PRRs). Of these, Toll-like receptors (TLRs) and nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) have shaped our current understanding of innate regulation of adaptive immunity. It is now recognized that PRRs are paramount in instructing an appropriate adaptive immune response. Their ligands have been the focus of adjuvant research… CONTINUE READING
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