Unknown primary tumors: establishment of cell lines, identification of chromosomal abnormalities, and implications for a second type of tumor progression.

@article{Bell1989UnknownPT,
  title={Unknown primary tumors: establishment of cell lines, identification of chromosomal abnormalities, and implications for a second type of tumor progression.},
  author={Carl W. Bell and Sen Pathak and Petter Frost},
  journal={Cancer research},
  year={1989},
  volume={49 15},
  pages={4311-5}
}
We describe the establishment of two human unknown primary tumor (UPT) cell lines and a comparison of their cytogenetic properties with two direct harvests from two tumor biopsy specimens. Histopathological analysis of all four tumor specimens revealed them to be undifferentiated adenocarcinomas of unknown origin. The chromosome numbers in these samples… CONTINUE READING